Why has my Twine 2 suddenly stopped working?

Hi all,

I haven't used Twine in a while and decided to start it up today and have a play with it. But it's suddenly not working. It won't start up at all. And I've tried a reinstallation, and then running in different windows compatibility modes, but it's still not running. Has anybody had this problem and if so, did you manage to find a solution? I'm on Windows 10.

Thanks!